COMPARING LARGE-SCALE COMPUTATIONAL APPROACHES TO EPIDEMIC MODELING: AGENT-BASED VERSUS STRUCTURED METAPOPULATION MODELS

Comparing large-scale computational approaches to epidemic modeling: Agent-based versus structured metapopulation models

Abstract Background In recent years large-scale computational models for the realistic simulation of epidemic outbreaks have been used with increased frequency.Methodologies adapt to the scale of interest and range from very detailed agent-based models to spatially-structured metapopulation models.One major issue thus concerns to what extent the ge

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Biological and Immunological Characterization of a Functional L-HN Derivative of Botulinum Neurotoxin Serotype F

Botulinum neurotoxins (BoNTs) can cause nerve paralysis syndrome in mammals and other vertebrates.BoNTs are the most toxic biotoxins known and are classified as Class A biological warfare agents.BoNTs are mainly divided into seven serotypes A-G and new neurotoxins BoNT/H and BoNT/X, which have similar functions.BoNT proteins are 150 kDa polypeptide

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